The Brain designs a mesmerizing doll, Noodle Noggin, and plans to have Santa Claus deliver one to every house so he can make people do his every command through mind control.
During a White House conference on the topic "the brain," one of the president's assistants mistakenly invites The Brain. After he becomes trapped in a web of conspiracy and deception, The Brain gets brainwashed and Pinky must save him.
The Brain and Pinky escape from the land of Hats, but find someone is still after them as they try to save the world from an evil dance, the Schmeerskahoven.
Pinky arrives in 1946 Vienna to search for The Brain and gets caught-up in a complicated mystery. Then; the Brain reunites with his parents and struggles to get along with them.
Animal rights activist think Pink and the Brain are monkeys and release them into the jungle after taking them out of Acme Labs. The pair try to make it back home, but run into the Brain's old enemy Snowball.
In a special Halloween episode, Pinky sells his soul so that The Brain can take over the world. The Brain challenges the devil to get Pinky's soul back.