- Daughter of David Mamet and Lindsay Crouse. Sister of Willa Mamet. Half-sister of Clara Mamet and Noah Mamet.
- In a January 2013 New York Times Magazine profile, Mamet said that her first name is pronounced ZAH-shah ("like Sasha with a Z").
- Zosia's father is Ashkenazi Jewish (from a family from Russia and Poland). Zosia's mother has English, Scots-Irish (Northern Irish), German, and Welsh ancestry.
- Her name pronounced as "ZAW-shah". It's nickname of Polish-Greek name Zofia meaning "wisdom".
- She grew up in Los Angeles.
- Stepdaughter of Rebecca Pidgeon.
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