Bingbing Li's entire dialogue was dubbed by Sally Cahill who voiced Ada Wong in the video games (Resident Evil 2 (1998), Resident Evil: The Darkside Chronicles (2009) and Resident Evil 4 (2005)). Although she can speak English, Li Bingbing had a thick accent, which required her to be audio dubbed as a result.
The character Becky was not originally to be hearing-impaired, but after an outstanding audition, the role was given to Aryana Engineer. She was scouted by Paul W.S. Anderson and Milla Jovovich, as they were impressed by her performance in Orphan (2009).
In the scene that takes place in the Oval Office, the Great Seal of the United States on the ground is modified so that the eagle's head faces its left foot, which is holding 13 arrows (symbolizing war), as opposed to its normal pose where it faces its right foot holding an olive branch (symbolizing peace).
While filming a fight scene with Milla Jovovich, a mishap occurred causing 16 actors to fall off a scaffolding and sent to the hospital. As a result, filming was shutdown for a few days and Jovovich visited some of the actors in the hospital out of respect.
(at around 52 mins) During the car chase with the Zombie Russian army the music playing is called 'Phantom Chase' by tomandandy. This references music from the original Resident Evil (1996) video game, particularly 'Second Floor Mansion'.