Opening Sequence of the film, Eddie and Doc are walking down a steep hill sidewalk and doc asks about "anything exciting" in Eddie's life. There are NO cars anywhere near them. The very next cut Eddie is answering the question and they are on a level sidewalk and there are cars parked in the street and behind them over doc's head. They also pass the same group of seated sidewalk coffee drinkers twice.
When Eddie is checking into the hotel you can see a boat passing in the ocean behind Tito, but when the camera cuts to Eddie then back to Tito the boat is gone, even though there wouldn't have been enough time for the boat to pass out of the scene.
During the breakup scene where Lila comments about the guacamole, the ice is visible in their water glasses at one camera angle and is melted in the next.
When Eddie and Miranda are crawling back onto shore (after Eddie jumps into the water to save Miranda), you see an overhead shot in which the back of Eddie's shirt is intact. Seconds later, the back of his shirt has a huge rip up the middle, revealing a jellyfish stuck to his back.
When Eddie's father walks in Miranda's room after Eddie gets caught at her bedside, his white cap is about to fall off while he says his line. In the next frame, his cap is suddenly perfectly straight again.
Miranda states she is drinking a Mind Eraser, however her drink is red and it has tequila in it - both not true. A Mind Eraser would not be either since it contains only vodka, coffee liqueur and soda water.
Miranda tells Eddie that she coaches the women's lacrosse team at Ole Miss, a.k.a. The University of Mississippi. Ole Miss does not have a women's (or men's) lacrosse team.
At the Sporting good store Eddie tells Ralph the pitch was high and inside and the kid swung over the ball by 2 feet.
Ben Stiller gets stung by a jellyfish, and Malin Akerman has to pee on him to make the pain stop. This could make it worse. Mayo Clinic suggests rinsing with SALT WATER, removing stingers, and then use hot water for the area.
Eddie said The Perfect Storm (2000) was shot off the Mexican resort but the movie was never filmed in Mexico. He was just saying that to discourage his wife from going on to the boat.
When Lila is wiping the cream off her face, you can see the red makeup used to create a sunburn on the towel she uses.
On the way to Mexico when Lila tells Eddie she wants him to find a hotel so they can have sex, the next shot shows their car taking the exit off the highway. There is however only one person still in the car and you can clearly see it is neither of the main characters but a stunt double.
The cable car that Lila boards is running on four rubber tires, not on the cable car track.
While Eddie and Lila are driving down to Mexico on the Highway, their car is filmed from the side, passing by. You can clearly see the reflection of the crane the camera was mounted on in their cars' side.
After the beach day when Eddie is having dinner with Miranda's family, you can see a lint roller sitting on the rock wall behind them.
When the couple is leaving on their Honeymoon, they drive along I580 by the Altamont Pass Wind Farm. The direction they are traveling would take them back into San Francisco.
When Miranda's cousin Buzz says he is opening another Subway on Route 122 near Oxford, MS. There is no Route 122 anywhere near Oxford.