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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- The sole survivor of a pier shoot-out tells the story of how a notorious criminal influenced the events that began with five criminals meeting in a seemingly random police lineup.
- The early years of James Logan, featuring his rivalry with his brother Victor Creed, his service in the special forces team Weapon X, and his experimentation into the metal-lined mutant Wolverine.
- In a world where mutants (evolved super-powered humans) exist and are discriminated against, two groups form for an inevitable clash: the supremacist Brotherhood, and the pacifist X-Men.
- In the 1960s, superpowered humans Charles Xavier and Erik Lensherr work together to find others like them, but Erik's vengeful pursuit of an ambitious mutant who ruined his life causes a schism to divide them.
- The X-Men send Wolverine to the past in a desperate effort to change history and prevent an event that results in doom for both humans and mutants.
- The human government develops a cure for mutations, and Jean Grey becomes a darker uncontrollable persona called the Phoenix who allies with Magneto, causing escalation into an all-out battle for the X-Men.
- In the 1980s the X-Men must defeat an ancient all-powerful mutant, En Sabah Nur, who intends to thrive through bringing destruction to the world.
- David Haller is a troubled young man diagnosed as schizophrenic, but after a strange encounter he discovers special powers that will change his life forever.
- When anti-mutant Colonel William Stryker kidnaps Professor X and attacks his school, the X-Men must ally with their archenemy Magneto to stop him.
- Wolverine comes to Japan to meet an old friend whose life he saved years ago, and gets embroiled in a conspiracy involving yakuza and mutants.
- Jean Grey begins to develop incredible powers that corrupt and turn her into a Dark Phoenix, causing the X-Men to have to decide if her life is worth more than all of humanity.
- A dramatization of the July 20, 1944 assassination and political coup plot by desperate renegade German Army officers against Adolf Hitler during World War II.
- In a world where mutated humans are treated with distrust and fear, an institute for mutants battles to achieve peaceful co-existence with humanity.
- Superman returns to Earth after spending five years in space examining his homeworld Krypton. But he finds things have changed while he was gone, and he must once again prove himself important to the world.
- The ancient war between humans and a race of giants is reignited when Jack, a young farmhand fighting for a kingdom and the love of a princess, opens a gateway between the two worlds.
- An elderly woman battling Alzheimer's disease agrees to let a film crew document her condition, but what they discover is something far more sinister going on.
- Five interwoven stories that occur on Halloween: an everyday high school principal has a secret life as a serial killer; a college virgin might have just met the guy for her; a group of teenagers pull a mean prank; a woman who loathes the night has to contend with her holiday-obsessed husband; and a mean old man meets his match with a demonic, supernatural trick-or-treater.
- A boy blackmails his neighbor after suspecting him to be a Nazi war criminal.
- Catherine Black, a famed neuroscientist with a job at the Center for Neurological Research and Treatment, struggles with mental illness. However, this is just one of the many secrets she hides from her fiancé and her family.
- A shipping magnate hires four experts from various fields to investigate what happened to his ships that went missing in the Bermuda Triangle. The team discovers a threat that might unravel time itself and cause the world to end.
- Grandpa Sam Dracula is essentially Dracula who assembled Herman because no man was good enough for his daughter Lily, a sexy vampiress. Lily's niece Marilyn the freak is actually normal and Lily and Herman's only child, Eddie, has his werewolf tendencies surface in puberty, forcing the family to relocate to their famous 1313 Mockingbird Lane address.
- A future-set story in which a virus has wiped out most of the human race, and those still alive have their minds linked to the Internet 24 hours a day. Here, a viral incident leads to a new world order.
- A teenage boy's descent into the dangerous world of the Internet and the harrowing consequences of his actions. A true story.
- Created as a companion documentary to the film Valkyrie, this documentary details the true story behind the plot to assassinate Adolph Hitler.
- A team of ghost hunters set out to investigate the awesomeness of the unknown.
- The history of the comic book superhero, Superman in his various media incarnations.
- A young man comes to terms with his sexuality and his hidden love for his best friend
- "Science of Superman" interviews the experts and uses highlights from comic books, television and film - including scenes from the 2006 summer blockbuster, "Superman Returns" - to examine the science behind the Man of Steel's extraordinary powers.
- House treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- The team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- A nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.
- When a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
- A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.
- Cuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."
- House has to deal with his promised dinner date with Cameron, a mysterious stroke in a clinic patient and a libidinous senior citizen.